Argireline
A topical 'Botox-in-a-bottle' peptide studied in expression-line cosmetic research.
Get told when a price moves or a lab test changes.
Observed median price
$210
Every observation
| Date | Observed |
|---|---|
| $214.96 | |
| $215.23 | |
| $39.99 | |
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| $127.61 | |
| $214.96 | |
| $212.48 | |
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| $212.48 | |
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| $212.48 | |
| $212.48 | |
| $212.48 | |
| $212.48 | |
| $212.48 | |
| $210.00 | |
| $210.00 | |
| $212.48 | |
| $210.00 | |
| $210.00 | |
| $210.00 | |
| $210.00 | |
| $210.00 | |
| $210.00 | |
| $210.00 | |
| $210.00 |
Not enough listings with 30 days of checks to summarise a change — 1 of 6 qualify so far.
6
Active listings
0
Independent lab tests
$40–$226
Observed price range
3
Known aliases
Understand this compound
What is Argireline?
Widely studieda.k.a. Acetyl Hexapeptide-8A skin-cream ingredient that works like a milder, rub-on cousin of Botox: it tells facial muscles to relax slightly so expression lines soften.
Good to know: Evidence is mixed and confounded by industry funding of the strongest positive trials, and low skin penetration limits how much active peptide reaches its target.
How does Argireline work?
The science
A synthetic hexapeptide fragment of SNAP-25 that competes with native SNAP-25 in the SNARE complex, reducing acetylcholine release at the neuromuscular junction and dampening facial muscle contraction — a topical, non-injected mimic of botulinum toxin's mechanism.
Mechanism of action from published research — how the molecule behaves, not a claim about any product or any human-use effect.
What is Argireline researched for?
Studied as a topical cosmetic ingredient for expression-line and wrinkle reduction.
- Skin & cosmeticStudied in cosmetic and skin research — collagen, elasticity, and appearance.
How far has the research gone?
Widely studied (cosmetic literature) — manufacturer-funded trials report wrinkle-depth reduction, but an independent 2023 evaluation found no significant effect, and skin penetration is a known limitation.
Where the science stands — an approved drug is not the same as the research-grade material a vendor sells, which is unregulated regardless.
What should I check before buying?
- Independent purity. Look for a third-party COA (Janoshik or MZ) showing a measured purity — not just a number the vendor typed.
- Batch match. The strongest evidence is a certificate for the exact batch you’ll receive, attributed to this vendor — check the cross-verification on the listing.
- Vendor reputation. See how the vendor is talked about in the community before trusting a new name.
Research context only — VialGrade never gives dosing, medical, or human-use guidance.
Current market
The Argireline market
Every Argireline listing we track — 6 in all. The standout picks first where the evidence supports them, then the full table, ranked by what a milligram really costs wherever the vendor published a strength we can read.
Open full marketAcetyl Hexapeptide-3 (Argireline) (200mg)
Biotech PeptidesC
$210$1.05/mg-4% vs median
Lowest price per mg that isn't flagged as suspiciously cheap.
In stockChecked 10 hours ago
ARGIRELINE PEPTIDE 10MG VIAL 10MG
Umbrella LabsC-
$40$4.00/mg+267% vs median
The most recently re-verified listing on this market.
In stockChecked 10 hours ago
Acetyl Hexapeptide-8 (Raw) – 1g
Ion PeptideC
$129$0.13/mg-88% vs median
Ranked #1 of 4 listings by price per milligram.
In stockChecked 10 hours ago
Acetyl Hexapeptide-3 (Argireline) – 200MG
Core PeptidesB+
$226$1.13/mg+4% vs median
Ranked #3 of 4 listings by price per milligram.
In stockChecked 10 hours ago
Compare by real cost
Every Argireline listing, cheapest per mg first
Sticker prices hide the size, so listings are ranked by what a milligram actually costs — with independently tested purity where it exists. All 6 are here: the last 2 are listings whose vendor never published a strength we can read, so they have no per-mg figure to sort on.
| # | Vendor | Size | Price | Per mg | Tested purity | Real $/active mg | |
|---|---|---|---|---|---|---|---|
| 1 | Ion Peptide | 1g total1g each | $129 | $0.13/mg · too cheap? | — | — | View |
| 2 | Biotech Peptides | 200mg total | $210 | $1.05/mg | — | — | View |
| 3 | Core Peptides | 200mg total | $226 | $1.13/mg | — | — | View |
| 4 | Umbrella Labs | 10mg total | $40 | $4.00/mg | — | — | View |
| Listed, but not rankable — no published strength to price per mg | |||||||
| — | Behemoth LabzUnavailable | 1 vial | $215 | no size published | — | — | View |
| — | Purerawz | 1 vial | $215 | no size published | — | — | View |
Open the full Argireline market
Real $/active mg divides the price-per-mg by the measured purity — the honest cost of the actual peptide, so a 90%-pure vial isn’t compared as if it were 99%. Too cheap? flags a listing far below the market rate — often underdosing or a fake, not a deal. The crown marks the cheapest non-outlier; best value marks the lowest real cost per active mg. A vendor shown as Unavailable or Low stock is priced here but not currently buyable.
What the research says
Scientific evidence & regulatory status
What the published literature actually shows about Argireline — separate from any vendor’s marketing. Each finding links to its paper. This is education, not medical or dosing advice.
Regulatory status
No FDA-approved drug
Not FDA-approved as a drug: acetyl hexapeptide-8 is used as a topical cosmetic ingredient, and US law requires no FDA approval for cosmetic ingredients other than color additives. It is listed in the EU cosmetic-ingredient database without any Annex restriction; no injectable or systemic use of it is authorized anywhere.
Research-use-only — not FDA-approved
Sold “for research use only,” this compound is not FDA-approved for human use and has not been evaluated for safety, purity, or sterility in people. It is generally not a scheduled controlled substance, so buying it as a research chemical is typically not itself a drug crime — but marketing or using it as a drug is not lawful, and it is not a dietary supplement.
General information, not legal or medical advice. VialGrade sells nothing and encourages no human use.
Research notes aren’t product proof
Research summaries describe published literature and market data only. They do not establish the identity, quality, safety, or legal status of any listed physical product.