Matrixyl
A collagen-fragment cosmetic peptide widely used in anti-wrinkle skincare research.
Get told when a price moves or a lab test changes.
Observed median price
$134
Every observation
| Date | Observed |
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| $19.10 | |
| $18.57 | |
| $75.99 | |
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| $47.28 | |
| $19.10 | |
| $129.00 | |
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| $134.00 | |
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Not enough listings with 30 days of checks to summarise a change — 1 of 7 qualify so far.
7
Active listings
0
Independent lab tests
$19–$190
Observed price range
4
Known aliases
Understand this compound
What is Matrixyl?
Widely studieda.k.a. Palmitoyl Pentapeptide-4A skincare ingredient that pairs a collagen-fragment 'rebuild' signal with a fatty tail that helps it sink into skin. Studied for softening wrinkles.
Good to know: Most trials are small and short-duration (about 12 weeks), and several of the strongest results are sponsored by the ingredient manufacturer (Sederma).
How does Matrixyl work?
The science
Palmitoyl pentapeptide-4 pairs a palmitic-acid tail for skin penetration with the KTTKS sequence, a natural procollagen I breakdown fragment that signals fibroblasts to sustain collagen synthesis.
Mechanism of action from published research — how the molecule behaves, not a claim about any product or any human-use effect.
What is Matrixyl researched for?
Studied as a topical cosmetic ingredient for collagen stimulation and improvement of wrinkle depth and skin roughness.
- Skin & cosmeticStudied in cosmetic and skin research — collagen, elasticity, and appearance.
How far has the research gone?
Widely studied (cosmetic literature) — multiple small controlled trials, including at least one independent (non-manufacturer) study, report improved wrinkle depth and collagen density over 12 weeks.
Where the science stands — an approved drug is not the same as the research-grade material a vendor sells, which is unregulated regardless.
What should I check before buying?
- Independent purity. Look for a third-party COA (Janoshik or MZ) showing a measured purity — not just a number the vendor typed.
- Batch match. The strongest evidence is a certificate for the exact batch you’ll receive, attributed to this vendor — check the cross-verification on the listing.
- Vendor reputation. See how the vendor is talked about in the community before trusting a new name.
Research context only — VialGrade never gives dosing, medical, or human-use guidance.
Current market
The Matrixyl market
Every Matrixyl listing we track — 7 in all. The standout picks first where the evidence supports them, then the full table, ranked by what a milligram really costs wherever the vendor published a strength we can read.
Open full marketMatrixyl – 200MG
Core PeptidesB+
$171$0.85/mg
Lowest price per mg that isn't flagged as suspiciously cheap.
In stockChecked 10 hours ago
PALMITOYL TRIPEPTIDE-38 (MATRIXYL SYNTHE 6) PEPTIDE 200MG VIAL 200MG
Umbrella LabsC-
$76$0.38/mg-56% vs median
The most recently re-verified listing on this market.
In stockChecked 10 hours ago
Palmitoyl Pentapeptide-4 (Raw) – 1000mg
Ion PeptideC
$139$0.14/mg-84% vs median
Ranked #1 of 5 listings by price per milligram.
In stockChecked 10 hours ago
Matrixyl (200mg)
Biotech PeptidesC
$190$0.95/mg+11% vs median
Ranked #4 of 5 listings by price per milligram.
In stockChecked 10 hours ago
Matrixyl – 10mg
Ion PeptideC
$129$12.9/mg+1409% vs median
Ranked #5 of 5 listings by price per milligram.
In stockChecked 10 hours ago
Compare by real cost
Every Matrixyl listing, cheapest per mg first
Sticker prices hide the size, so listings are ranked by what a milligram actually costs — with independently tested purity where it exists. All 7 are here: the last 2 are listings whose vendor never published a strength we can read, so they have no per-mg figure to sort on.
| # | Vendor | Size | Price | Per mg | Tested purity | Real $/active mg | |
|---|---|---|---|---|---|---|---|
| 1 | Ion Peptide | 1g total | $139 | $0.14/mg · too cheap? | — | — | View |
| 2 | Umbrella Labs | 200mg total | $76 | $0.38/mg · too cheap? | — | — | View |
| 3 | Core Peptides | 200mg total | $171 | $0.85/mg | — | — | View |
| 4 | Biotech Peptides | 200mg total | $190 | $0.95/mg | — | — | View |
| 5 | Ion Peptide | 10mg total | $129 | $12.9/mg | — | — | View |
| Listed, but not rankable — no published strength to price per mg | |||||||
| — | Purerawz | 1 vial | $19 | no size published | — | — | View |
| — | Behemoth LabzUnavailable | 1 vial | $19 | no size published | — | — | View |
Real $/active mg divides the price-per-mg by the measured purity — the honest cost of the actual peptide, so a 90%-pure vial isn’t compared as if it were 99%. Too cheap? flags a listing far below the market rate — often underdosing or a fake, not a deal. The crown marks the cheapest non-outlier; best value marks the lowest real cost per active mg. A vendor shown as Unavailable or Low stock is priced here but not currently buyable.
What the research says
Scientific evidence & regulatory status
What the published literature actually shows about Matrixyl — separate from any vendor’s marketing. Each finding links to its paper. This is education, not medical or dosing advice.
Regulatory status
No FDA-approved drug
Not FDA-approved as a drug: palmitoyl pentapeptide-4 is used as a topical cosmetic ingredient, and US law requires no FDA approval for cosmetic ingredients other than color additives. It is listed in the EU cosmetic-ingredient database without any Annex restriction; no injectable or systemic use of it is authorized anywhere.
Research-use-only — not FDA-approved
Sold “for research use only,” this compound is not FDA-approved for human use and has not been evaluated for safety, purity, or sterility in people. It is generally not a scheduled controlled substance, so buying it as a research chemical is typically not itself a drug crime — but marketing or using it as a drug is not lawful, and it is not a dietary supplement.
General information, not legal or medical advice. VialGrade sells nothing and encourages no human use.
Research notes aren’t product proof
Research summaries describe published literature and market data only. They do not establish the identity, quality, safety, or legal status of any listed physical product.