P21
A CNTF-derived peptidomimetic studied in neurogenesis research.
Get told when a price moves or a lab test changes.
Observed median price
$98
Every observation
| Date | Observed |
|---|---|
| $62.48 | |
| $89.87 |
Not enough listings with 30 days of checks to summarise a change — 0 of 3 qualify so far.
3
Active listings
0
Independent lab tests
$62–$117
Observed price range
3
Known aliases
Understand this compound
What is P21?
Preclinical / animal onlya.k.a. TFP5 (related fragment)A brain-protection molecule designed to block an enzyme that goes haywire and kills neurons after strokes and in neurodegenerative disease. Animal research only.
Good to know: Research is confined to animal models of stroke and neurodegeneration; no human safety or efficacy data exist.
How does P21 work?
The science
A peptide derived from the CDK5-activating cofactor p35, designed to inhibit pathological CDK5/p25 hyperactivity implicated in neuronal apoptosis after injury or in neurodegeneration.
Mechanism of action from published research — how the molecule behaves, not a claim about any product or any human-use effect.
What is P21 researched for?
Studied for neuroprotection in ischemic stroke and neurodegenerative disease models, including Alzheimer's and Parkinson's.
- Cognitive & moodStudied in memory, focus, mood, and neuroprotection research.
How far has the research gone?
Preclinical / animal research — efficacy shown in rodent stroke and Parkinson's models (often via the related peptide 'TFP5'), with no identified human trials.
Where the science stands — an approved drug is not the same as the research-grade material a vendor sells, which is unregulated regardless.
What should I check before buying?
- Independent purity. Look for a third-party COA (Janoshik or MZ) showing a measured purity — not just a number the vendor typed.
- Batch match. The strongest evidence is a certificate for the exact batch you’ll receive, attributed to this vendor — check the cross-verification on the listing.
- Vendor reputation. See how the vendor is talked about in the community before trusting a new name.
Research context only — VialGrade never gives dosing, medical, or human-use guidance.
Current market
The P21 market
Every P21 listing we track — 3 in all. The standout picks first where the evidence supports them, then the full table, ranked by what a milligram really costs wherever the vendor published a strength we can read.
Open full marketCompare by real cost
Every P21 listing, cheapest per mg first
Sticker prices hide the size, so listings are ranked by what a milligram actually costs — with independently tested purity where it exists. All 3 are here: the last 2 are listings whose vendor never published a strength we can read, so they have no per-mg figure to sort on.
| # | Vendor | Size | Price | Per mg | Tested purity | Real $/active mg | |
|---|---|---|---|---|---|---|---|
| 1 | PurerawzUnavailable | 10mg total | $117 | $11.7/mg | — | — | View |
| Listed, but not rankable — no published strength to price per mg | |||||||
| — | PurerawzUnavailable | 1 vial | $62 | no size published | — | — | View |
| — | Modern AminosUnavailable | 1 vial | $98 | no size published | — | — | View |
Real $/active mg divides the price-per-mg by the measured purity — the honest cost of the actual peptide, so a 90%-pure vial isn’t compared as if it were 99%. Too cheap? flags a listing far below the market rate — often underdosing or a fake, not a deal. The crown marks the cheapest non-outlier; best value marks the lowest real cost per active mg. A vendor shown as Unavailable or Low stock is priced here but not currently buyable.
What the research says
Scientific evidence & regulatory status
What the published literature actually shows about P21 — separate from any vendor’s marketing. Each finding links to its paper. This is education, not medical or dosing advice.
Regulatory status
No FDA-approved drug
Not FDA-approved and no approval by any other regulator was identified; an experimental neuro-active peptide with no registered human trials on ClinicalTrials.gov, sold as research-use-only material.
Research-use-only — not FDA-approved
Sold “for research use only,” this compound is not FDA-approved for human use and has not been evaluated for safety, purity, or sterility in people. It is generally not a scheduled controlled substance, so buying it as a research chemical is typically not itself a drug crime — but marketing or using it as a drug is not lawful, and it is not a dietary supplement.
General information, not legal or medical advice. VialGrade sells nothing and encourages no human use.
Research notes aren’t product proof
Research summaries describe published literature and market data only. They do not establish the identity, quality, safety, or legal status of any listed physical product.