Semaglutide
The GLP-1 analog behind Ozempic and Wegovy — the most-searched compound in weight and metabolic research.
Get told when a price moves or a lab test changes.
Observed median price
$170
Every observation
| Date | Observed |
|---|---|
| $90.00 | |
| $99.99 | |
| $159.99 | |
| $160.00 | |
| $170.00 | |
| $125.00 | |
| $125.00 | |
| $125.00 | |
| $125.00 | |
| $160.00 | |
| $160.00 | |
| $125.00 | |
| $160.00 | |
| $160.00 | |
| $125.00 | |
| $125.00 | |
| $125.00 | |
| $160.00 | |
| $160.00 | |
| $125.00 | |
| $125.00 | |
| $125.00 | |
| $160.00 | |
| $160.00 | |
| $125.00 | |
| $125.00 | |
| $160.00 | |
| $125.00 | |
| $125.00 | |
| $160.00 | |
| $125.00 | |
| $160.00 | |
| $125.00 | |
| $160.00 | |
| $125.00 | |
| $160.00 | |
| $125.00 |
Median of 4 listings' 30-day changes; 5 excluded for insufficient history.
9
Active listings
6 · 99.6%
Independent lab tests
$90–$330
Observed price range
5
Known aliases
Read from the certificate, not re-measured by VialGrade. Purity is not a grade. Purity vs grade
Understand this compound
What is Semaglutide?
FDA-approved moleculea.k.a. Ozempic, Wegovy, RybelsusThe molecule behind Ozempic and Wegovy — a lab-made version of a gut fullness hormone that quiets appetite. The pharmacy product is FDA-approved; grey-market vials of it are not.
Good to know: GI side effects (nausea, vomiting) are common in trials, and long-term safety of non-pharmaceutical-grade research material is unverified and unregulated.
How does Semaglutide work?
The science
A GLP-1 receptor agonist; mimics the endogenous incretin hormone GLP-1 to stimulate glucose-dependent insulin secretion, suppress glucagon, slow gastric emptying, and signal satiety via hypothalamic GLP-1 receptors.
Mechanism of action from published research — how the molecule behaves, not a claim about any product or any human-use effect.
What is Semaglutide researched for?
Studied for glycemic control in type-2 diabetes and for chronic weight management, with further research into cardiovascular risk reduction, MASH/liver fat, and addiction/reward pathways.
- Weight & metabolicStudied in weight, appetite, blood-sugar, and fat-metabolism research.
How far has the research gone?
FDA-approved (for type-2 diabetes and obesity); approved as Ozempic/Rybelsus for type-2 diabetes and Wegovy for chronic weight management.
Where the science stands — an approved drug is not the same as the research-grade material a vendor sells, which is unregulated regardless.
What should I check before buying?
- Independent purity. Look for a third-party COA (Janoshik or MZ) showing a measured purity — not just a number the vendor typed.
- Batch match. The strongest evidence is a certificate for the exact batch you’ll receive, attributed to this vendor — check the cross-verification on the listing.
- Vendor reputation. See how the vendor is talked about in the community before trusting a new name.
Research context only — VialGrade never gives dosing, medical, or human-use guidance.
Current market
The Semaglutide market
Every Semaglutide listing we track — 9 in all. The standout picks first where the evidence supports them, then the full table, ranked by what a milligram really costs wherever the vendor published a strength we can read.
Open full marketSEMAGLUTIDE PEPTIDE VIAL 20mg Peptide Vial
Umbrella LabsC-
$226$11.3/mg-37% vs median
Lowest price per mg that isn't flagged as suspiciously cheap.
In stockChecked 3 days ago
SEMAGLUTIDE PEPTIDE POWDER (30 TABLETS) 30 Tablets (7mg/tablet)
Umbrella LabsC-
$160$0.76/mg-96% vs median
Lowest real cost per active mg — price divided by measured purity.
UnavailableChecked 1 month ago
Semaglutide (GLP-1 Analogue) 6mg
Nootropic SourceC-
$160$26.7/mg+48% vs median
The most recently re-verified listing on this market.
In stockChecked 7 hours ago
SEMAGLUTIDE PEPTIDE POWDER (30 TABLETS) 30 Tablets (14mg/tablet)
Umbrella LabsC-
$330$0.79/mg-96% vs median
Ranked #2 of 8 listings by price per milligram.
In stockChecked 1 day ago
SEMAGLUTIDE PEPTIDE VIAL 15mg Peptide Vial
Umbrella LabsC-
$200$13.3/mg-26% vs median
Ranked #4 of 8 listings by price per milligram.
In stockChecked 3 days ago
Compare by real cost
Every Semaglutide listing, cheapest per mg first
Sticker prices hide the size, so listings are ranked by what a milligram actually costs — with independently tested purity where it exists. All 9 are here: the last 1 is a listing whose vendor never published a strength we can read, so it has no per-mg figure to sort on.
| # | Vendor | Size | Price | Per mg | Tested purity | Real $/active mg | |
|---|---|---|---|---|---|---|---|
| 1 | Umbrella LabsUnavailable | 210mg total30 Tablets (7mg/tablet) each | $160 | $0.76/mg · too cheap? | — | $0.76/mgbest value | View |
| 2 | Umbrella Labs | 420mg total30 Tablets (14mg/tablet) each | $330 | $0.79/mg · too cheap? | — | $0.79/mg | View |
| 3 | Umbrella Labs | 20mg total | $226 | $11.3/mg | — | $11.3/mg | View |
| 4 | Umbrella Labs | 15mg total | $200 | $13.3/mg | — | $13.4/mg | View |
| 5 | Umbrella Labs | 10mg total | $180 | $18.0/mg | — | $18.1/mg | View |
| 6 | Umbrella Labs | 5mg total | $100 | $20.0/mg | — | $20.1/mg | View |
| 7 | Nootropic Source | 6mg total | $160 | $26.7/mg | — | $26.8/mg | View |
| 8 | Nootropic Source | 3mg total | $90 | $30.0/mg | — | $30.1/mg | View |
| Listed, but not rankable — no published strength to price per mg | |||||||
| — | Umbrella Labs | 1 vial | $160 | no size published | — | — | View |
Open the full Semaglutide market
Real $/active mg divides the price-per-mg by the measured purity — the honest cost of the actual peptide, so a 90%-pure vial isn’t compared as if it were 99%. Too cheap? flags a listing far below the market rate — often underdosing or a fake, not a deal. The crown marks the cheapest non-outlier; best value marks the lowest real cost per active mg. A vendor shown as Unavailable or Low stock is priced here but not currently buyable.
Independent testing
Semaglutide — independent lab tests
Real, publicly verifiable third-party tests. Purity is read from the certificate itself. A test reflects one lab’s result for one submitted batch — not a guarantee that every vial matches.
How does this data get here?
Every record below is a real certificate of analysis, gathered two ways: from the public verification feeds that independent labs (like Janoshik) publish, and from the certificates vendors post on their own product pages. We open each certificate document and read the measured purity, content, batch, and date directly off it — a scraper can’t read a number printed inside an image, so this is done by machine vision, then recorded here with a link back to the original.
Nothing here is typed in by a vendor or invented by us. Where a certificate is missing, we say so rather than filling the gap.
We re-check the lab feed, too. A “still listed” tag means the certificate is currently public in Janoshik’s database — we re-verify against the live feed and stamp the date. If a cert is later pulled, the tag flips. It’s a freshness check on the same source, not a second independent opinion.
What a certificate does & doesn’t prove
Three different questions. Purity (“how clean?”), identity (“is it the right molecule?”, a mass-spec test), and content (“did I get the labeled mg?”) are separate. A vial can be 99% pure and still be the wrong peptide, or the right peptide underdosed. We flag the measured dose against the label above; underdosing is the most common real fraud.
Who submitted the sample matters. Most of these are vendor-submitted — the seller chose which vial to send, so one good certificate doesn’t prove every batch is the same. The gold standard is a blind test, where a buyer sends a vial they bought as a normal customer. Same label doesn’t prove same product; same batch number doesn’t prove same batch.
4
blind tests
99.9%
highest tested purity
| Certificate | Manufacturer | Batch | Purity | Content / dose | Lab | |
|---|---|---|---|---|---|---|
| Alpha BioPharma Blind | BBSXADDG | 99.89% | 10.10 mg | Janoshik Analytical Still listed | Verify | |
| www.certapeptides.com Blind | CP-2604-SEM5 | 99.26% | 5.23/5mg · full | Janoshik Analytical Still listed | Verify | |
| longevityprolabs.com Blind | — | See report | — | Janoshik Analytical | Verify | |
| longevityprolabs.com Blind | — | See report | — | Janoshik Analytical | Verify | |
| Simple Peptide | 20240604 | 99.81% | — | Freedom Diagnostics Testing | Verify | |
| Peptide Pros | 2023-06-22 | 99.40% | — | MZ Biolabs | Verify |
Tested batches
Batch test records for Semaglutide
The full test history for one batch — who picked the sample, who tested it, and what came back. It describes the vials that were tested, never every vial they sold.
What the research says
Scientific evidence & regulatory status
What the published literature actually shows about Semaglutide — separate from any vendor’s marketing. Each finding links to its paper. This is education, not medical or dosing advice.
Regulatory status
An approved drug exists — this is not it
FDA-approved as Ozempic and Rybelsus for type 2 diabetes (NDA 213051) and as Wegovy for chronic weight management (NDA 215256). Those are prescription products dispensed by a pharmacy. Research-grade semaglutide sold online is not any of them, and compounded or research semaglutide is the subject of a standing FDA warning.
Honest overall read
Strong, large-scale human RCT evidence supports substantial weight loss and a documented cardiovascular benefit; the main established harms are GI side effects and gallbladder disease, and weight tends to return after stopping.
In the 68-week STEP 1 RCT of 1,961 adults with overweight/obesity, once-weekly semaglutide 2.4 mg produced a mean body-weight change of -14.9% versus -2.4% with placebo, with 86% of treated participants losing at least 5%.
Nausea and diarrhea were the most common adverse events (usually transient); gallbladder disorders were more frequent with semaglutide.
read the sourceIn the SELECT trial of 17,604 adults with established cardiovascular disease and overweight/obesity but without diabetes, semaglutide 2.4 mg reduced major adverse cardiovascular events by 20% (6.5% vs 8.0%; HR 0.80) over a mean 39.8 months.
More participants discontinued for adverse events (chiefly GI) than placebo; population was mostly older men with prior CVD, so results may not generalize.
read the sourceReference source
Semaglutide is the active ingredient in FDA-approved medicines made by Novo Nordisk (Ozempic, Wegovy, Rybelsus). Grey-market “Semaglutide” sold for research is not Novo Nordisk’s product and is not the FDA-approved drug — a different, unregulated supply chain under the same chemical name. See what pharmaceutical-grade means →
Commonly researched together
Often stacked with Semaglutide
Compounds the research community frequently discusses alongside Semaglutide. Not a protocol or a recommendation — a starting point for what to read about next.
This is a prescription drug in the US
This is the active drug in Ozempic and Wegovy — an FDA-approved prescription medication. Buying a “research” version sidesteps the prescription requirement and the approved, quality-controlled supply chain. The FDA has warned about and acted against unapproved and compounded copies. Higher legal and safety exposure than an unapproved research peptide.
General information, not legal or medical advice. VialGrade sells nothing and encourages no human use.
Research notes aren’t product proof
Research summaries describe published literature and market data only. They do not establish the identity, quality, safety, or legal status of any listed physical product.