Live data — every record is aggregated from real public sources. VialGrade never sells; it links out to the vendor.
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All compounds
GLP-1 / metabolic
Live data

Semaglutide

Weight & metabolic

The GLP-1 analog behind Ozempic and Wegovy — the most-searched compound in weight and metabolic research.

OzempicWegovyRybelsusNN9535

Get told when a price moves or a lab test changes.

Observed median price

$170

0.0 % · 30d
Every observation
DateObserved
$90.00
$99.99
$159.99
$160.00
$170.00
$125.00
$125.00
$125.00
$125.00
$160.00
$160.00
$125.00
$160.00
$160.00
$125.00
$125.00
$125.00
$160.00
$160.00
$125.00
$125.00
$125.00
$160.00
$160.00
$125.00
$125.00
$160.00
$125.00
$125.00
$160.00
$125.00
$160.00
$125.00
$160.00
$125.00
$160.00
$125.00

Median of 4 listings' 30-day changes; 5 excluded for insufficient history.

9

Active listings

6 · 99.6%

Independent lab tests

$90–$330

Observed price range

5

Known aliases

Read from the certificate, not re-measured by VialGrade. Purity is not a grade. Purity vs grade

Understand this compound

What is Semaglutide?

FDA-approved moleculea.k.a. Ozempic, Wegovy, Rybelsus

The molecule behind Ozempic and Wegovy — a lab-made version of a gut fullness hormone that quiets appetite. The pharmacy product is FDA-approved; grey-market vials of it are not.

Weight & metabolic
⚠

Good to know: GI side effects (nausea, vomiting) are common in trials, and long-term safety of non-pharmaceutical-grade research material is unverified and unregulated.

How does Semaglutide work?

The science

A GLP-1 receptor agonist; mimics the endogenous incretin hormone GLP-1 to stimulate glucose-dependent insulin secretion, suppress glucagon, slow gastric emptying, and signal satiety via hypothalamic GLP-1 receptors.

Mechanism of action from published research — how the molecule behaves, not a claim about any product or any human-use effect.

What is Semaglutide researched for?

Studied for glycemic control in type-2 diabetes and for chronic weight management, with further research into cardiovascular risk reduction, MASH/liver fat, and addiction/reward pathways.

  • Weight & metabolicStudied in weight, appetite, blood-sugar, and fat-metabolism research.
How far has the research gone?

FDA-approved (for type-2 diabetes and obesity); approved as Ozempic/Rybelsus for type-2 diabetes and Wegovy for chronic weight management.

Where the science stands — an approved drug is not the same as the research-grade material a vendor sells, which is unregulated regardless.

What should I check before buying?
  • Independent purity. Look for a third-party COA (Janoshik or MZ) showing a measured purity — not just a number the vendor typed.
  • Batch match. The strongest evidence is a certificate for the exact batch you’ll receive, attributed to this vendor — check the cross-verification on the listing.
  • Vendor reputation. See how the vendor is talked about in the community before trusting a new name.

Research context only — VialGrade never gives dosing, medical, or human-use guidance.

Current market

The Semaglutide market

Every Semaglutide listing we track — 9 in all. The standout picks first where the evidence supports them, then the full table, ranked by what a milligram really costs wherever the vendor published a strength we can read.

Open full market

Compare by real cost

Every Semaglutide listing, cheapest per mg first

Sticker prices hide the size, so listings are ranked by what a milligram actually costs — with independently tested purity where it exists. All 9 are here: the last 1 is a listing whose vendor never published a strength we can read, so it has no per-mg figure to sort on.

#VendorSizePricePer mgTested purityReal $/active mg
1Umbrella LabsUnavailable210mg total30 Tablets (7mg/tablet) each$160$0.76/mg · too cheap?—$0.76/mgbest valueView
2Umbrella Labs420mg total30 Tablets (14mg/tablet) each$330$0.79/mg · too cheap?—$0.79/mgView
3Umbrella Labs20mg total$226$11.3/mg—$11.3/mgView
4Umbrella Labs15mg total$200$13.3/mg—$13.4/mgView
5Umbrella Labs10mg total$180$18.0/mg—$18.1/mgView
6Umbrella Labs5mg total$100$20.0/mg—$20.1/mgView
7Nootropic Source6mg total$160$26.7/mg—$26.8/mgView
8Nootropic Source3mg total$90$30.0/mg—$30.1/mgView
Listed, but not rankable — no published strength to price per mg
—Umbrella Labs1 vial$160no size published——View

Open the full Semaglutide market

Real $/active mg divides the price-per-mg by the measured purity — the honest cost of the actual peptide, so a 90%-pure vial isn’t compared as if it were 99%. Too cheap? flags a listing far below the market rate — often underdosing or a fake, not a deal. The crown marks the cheapest non-outlier; best value marks the lowest real cost per active mg. A vendor shown as Unavailable or Low stock is priced here but not currently buyable.

Independent testing

Semaglutide — independent lab tests

Real, publicly verifiable third-party tests. Purity is read from the certificate itself. A test reflects one lab’s result for one submitted batch — not a guarantee that every vial matches.

How does this data get here?

Every record below is a real certificate of analysis, gathered two ways: from the public verification feeds that independent labs (like Janoshik) publish, and from the certificates vendors post on their own product pages. We open each certificate document and read the measured purity, content, batch, and date directly off it — a scraper can’t read a number printed inside an image, so this is done by machine vision, then recorded here with a link back to the original.

Nothing here is typed in by a vendor or invented by us. Where a certificate is missing, we say so rather than filling the gap.

We re-check the lab feed, too. A “still listed” tag means the certificate is currently public in Janoshik’s database — we re-verify against the live feed and stamp the date. If a cert is later pulled, the tag flips. It’s a freshness check on the same source, not a second independent opinion.

What a certificate does & doesn’t prove

Three different questions. Purity (“how clean?”), identity (“is it the right molecule?”, a mass-spec test), and content (“did I get the labeled mg?”) are separate. A vial can be 99% pure and still be the wrong peptide, or the right peptide underdosed. We flag the measured dose against the label above; underdosing is the most common real fraud.

Who submitted the sample matters. Most of these are vendor-submitted — the seller chose which vial to send, so one good certificate doesn’t prove every batch is the same. The gold standard is a blind test, where a buyer sends a vial they bought as a normal customer. Same label doesn’t prove same product; same batch number doesn’t prove same batch.

4

blind tests

99.9%

highest tested purity

CertificateManufacturerBatchPurityContent / doseLab
Alpha BioPharma BlindBBSXADDG99.89%10.10 mgJanoshik Analytical Still listed Verify
www.certapeptides.com BlindCP-2604-SEM599.26%5.23/5mg · fullJanoshik Analytical Still listed Verify
longevityprolabs.com Blind—See report—Janoshik Analytical Verify
longevityprolabs.com Blind—See report—Janoshik Analytical Verify
Simple Peptide2024060499.81%—Freedom Diagnostics Testing Verify
Peptide Pros2023-06-2299.40%—MZ Biolabs Verify

Tested batches

Batch test records for Semaglutide

The full test history for one batch — who picked the sample, who tested it, and what came back. It describes the vials that were tested, never every vial they sold.

All batch records

What the research says

Scientific evidence & regulatory status

What the published literature actually shows about Semaglutide — separate from any vendor’s marketing. Each finding links to its paper. This is education, not medical or dosing advice.

Regulatory status

An approved drug exists — this is not it

FDA-approved as Ozempic and Rybelsus for type 2 diabetes (NDA 213051) and as Wegovy for chronic weight management (NDA 215256). Those are prescription products dispensed by a pharmacy. Research-grade semaglutide sold online is not any of them, and compounded or research semaglutide is the subject of a standing FDA warning.

Honest overall read

Strong, large-scale human RCT evidence supports substantial weight loss and a documented cardiovascular benefit; the main established harms are GI side effects and gallbladder disease, and weight tends to return after stopping.

Human RCTOnce-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1). N Engl J Med. 2021.

In the 68-week STEP 1 RCT of 1,961 adults with overweight/obesity, once-weekly semaglutide 2.4 mg produced a mean body-weight change of -14.9% versus -2.4% with placebo, with 86% of treated participants losing at least 5%.

Nausea and diarrhea were the most common adverse events (usually transient); gallbladder disorders were more frequent with semaglutide.

read the source
Human RCTSemaglutide and Cardiovascular Outcomes in Obesity without Diabetes (SELECT). N Engl J Med. 2023.

In the SELECT trial of 17,604 adults with established cardiovascular disease and overweight/obesity but without diabetes, semaglutide 2.4 mg reduced major adverse cardiovascular events by 20% (6.5% vs 8.0%; HR 0.80) over a mean 39.8 months.

More participants discontinued for adverse events (chiefly GI) than placebo; population was mostly older men with prior CVD, so results may not generalize.

read the source

Reference source

Semaglutide is the active ingredient in FDA-approved medicines made by Novo Nordisk (Ozempic, Wegovy, Rybelsus). Grey-market “Semaglutide” sold for research is not Novo Nordisk’s product and is not the FDA-approved drug — a different, unregulated supply chain under the same chemical name. See what pharmaceutical-grade means →

Commonly researched together

Often stacked with Semaglutide

Compounds the research community frequently discusses alongside Semaglutide. Not a protocol or a recommendation — a starting point for what to read about next.

US legal statusBanned in drug-tested sport (WADA/USADA)

This is a prescription drug in the US

This is the active drug in Ozempic and Wegovy — an FDA-approved prescription medication. Buying a “research” version sidesteps the prescription requirement and the approved, quality-controlled supply chain. The FDA has warned about and acted against unapproved and compounded copies. Higher legal and safety exposure than an unapproved research peptide.

Read the full US law →

General information, not legal or medical advice. VialGrade sells nothing and encourages no human use.

Research notes aren’t product proof

Research summaries describe published literature and market data only. They do not establish the identity, quality, safety, or legal status of any listed physical product.