Tesofensine
A triple monoamine reuptake inhibitor studied in appetite and weight research.
Get told when a price moves or a lab test changes.
Observed median price
$110
Every observation
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Median of 5 listings' 30-day changes; 5 excluded for insufficient history.
10
Active listings
0
Independent lab tests
$77–$168
Observed price range
2
Known aliases
Understand this compound
What is Tesofensine?
In clinical trialsa.k.a. Tesomet (fixed-dose combination with metoprolol)An appetite-suppressing weight-loss pill that raises three brain chemicals at once. It worked in trials but stalled in the US over raised heart rate and blood pressure.
Good to know: Phase 2 data showed elevated heart rate and blood pressure, which is why US development stalled; cardiovascular safety remains the central open question.
How does Tesofensine work?
The science
A triple monoamine reuptake inhibitor; blocks reuptake of serotonin, norepinephrine, and dopamine to suppress appetite and modestly raise energy expenditure.
Mechanism of action from published research — how the molecule behaves, not a claim about any product or any human-use effect.
What is Tesofensine researched for?
Studied for obesity and weight loss, typically as a fixed-dose combination with the beta-blocker metoprolol (Tesomet) to offset cardiovascular effects.
- Weight & metabolicStudied in weight, appetite, blood-sugar, and fat-metabolism research.
- Cognitive & moodStudied in memory, focus, mood, and neuroprotection research.
How far has the research gone?
In clinical trials outside the US; Phase 3 ongoing for the Tesomet combination, but there is no active US Phase 3 program and it is not FDA-approved.
Where the science stands — an approved drug is not the same as the research-grade material a vendor sells, which is unregulated regardless.
What should I check before buying?
- Independent purity. Look for a third-party COA (Janoshik or MZ) showing a measured purity — not just a number the vendor typed.
- Batch match. The strongest evidence is a certificate for the exact batch you’ll receive, attributed to this vendor — check the cross-verification on the listing.
- Vendor reputation. See how the vendor is talked about in the community before trusting a new name.
Research context only — VialGrade never gives dosing, medical, or human-use guidance.
Current market
The Tesofensine market
Every Tesofensine listing we track — 10 in all. The standout picks first where the evidence supports them, then the full table, ranked by what a milligram really costs wherever the vendor published a strength we can read.
Open full marketTesofensine 500mcg (100 tabs/bottle)
EZ PeptidesA
$168$3.36/mg-58% vs median
Lowest price per mg that isn't flagged as suspiciously cheap.
UnavailableChecked 10 hours ago
TESOFENSINE POWDER (60 CAPSULES) (250MCG/CAPSULE, 15MG TOTAL)
Umbrella LabsC-
$80$5.33/mg-34% vs median
The most recently re-verified listing on this market.
In stockChecked 10 hours ago
Tesofensine + Taurine + Magnesium L-Threonate Capsules 425.125mg per capsule/60ct/25.5075g
PureRawzC-
$154$0.006/mg-100% vs median
Ranked #1 of 6 listings by price per milligram.
In stockChecked 11 days ago
Tesofensine (0.25mg/capsule), 60 Capsules
Swiss ChemsC-
$121$8.07/mg
Ranked #4 of 6 listings by price per milligram.
In stockChecked 10 hours ago
Tesofensine Tablets · 250mcg per tablet/60ct/15mg
PureRawzC-
$157$10.4/mg+29% vs median
Ranked #5 of 6 listings by price per milligram.
In stockChecked 11 days ago
Compare by real cost
Every Tesofensine listing, cheapest per mg first
Sticker prices hide the size, so listings are ranked by what a milligram actually costs — with independently tested purity where it exists. All 10 are here: the last 4 are listings whose vendor never published a strength we can read, so they have no per-mg figure to sort on.
| # | Vendor | Size | Price | Per mg | Tested purity | Real $/active mg | |
|---|---|---|---|---|---|---|---|
| 1 | Purerawz | 25.51g total425.125mg per capsule/60ct/25.5075g each | $154 | $0.006/mg · too cheap? | — | — | View |
| 2 | Ez PeptidesUnavailable | 50mg total500mcg each | $168 | $3.36/mg | — | — | View |
| 3 | Umbrella Labs | 15mg total250MCG each | $80 | $5.33/mg | — | — | View |
| 4 | Swiss Chems | 15mg total0.25mg each | $121 | $8.07/mg | — | — | View |
| 5 | Purerawz | 15mg totalTablets · 250mcg per tablet/60ct/15mg each | $157 | $10.4/mg | — | — | View |
| 6 | Modern Aminos | 500mcg total | $139 | $278.0/mg | — | — | View |
| Listed, but not rankable — no published strength to price per mg | |||||||
| — | Purerawz | 1 vial | $77 | no size published | — | — | View |
| — | Modern Aminos | 1 vial | $79 | no size published | — | — | View |
| — | Umbrella Labs | 30ML | $100 | no size published | — | — | View |
| — | Simple PeptideUnavailable | 1 vial | $150 | no size published | — | — | View |
Open the full Tesofensine market
Real $/active mg divides the price-per-mg by the measured purity — the honest cost of the actual peptide, so a 90%-pure vial isn’t compared as if it were 99%. Too cheap? flags a listing far below the market rate — often underdosing or a fake, not a deal. The crown marks the cheapest non-outlier; best value marks the lowest real cost per active mg. A vendor shown as Unavailable or Low stock is priced here but not currently buyable.
What the research says
Scientific evidence & regulatory status
What the published literature actually shows about Tesofensine — separate from any vendor’s marketing. Each finding links to its paper. This is education, not medical or dosing advice.
Regulatory status
No FDA-approved drug
Not FDA-approved and not approved by any regulator identified; an investigational triple monoamine-reuptake inhibitor whose developer has stated its Mexican marketing application was not approved. WADA prohibits tesofensine in competition as a stimulant (S6).
Research-use-only — not FDA-approved
Sold “for research use only,” this compound is not FDA-approved for human use and has not been evaluated for safety, purity, or sterility in people. It is generally not a scheduled controlled substance, so buying it as a research chemical is typically not itself a drug crime — but marketing or using it as a drug is not lawful, and it is not a dietary supplement.
General information, not legal or medical advice. VialGrade sells nothing and encourages no human use.
Research notes aren’t product proof
Research summaries describe published literature and market data only. They do not establish the identity, quality, safety, or legal status of any listed physical product.